Medical student Sarah Goodall is grieving her mother's death when she is assigned to write an essay on how the world came into being. Now, questioning her faith and her purpose, Sarah watches her life spiral downward, and a growing relationship with the mysterious bad boy Dane only adds to Sarah's confusion. Once an honor student, she begins failing her classes, jeopardizing her scholarship and her future. Then, an American transfer student, Mike, takes a vested interest in Sarah and helps her rediscover what she's counted as lost.
Creationism is a central theme in Charge Over You, which takes its title from Psalm 91:11, "For he shall give his angels charge over you, to keep you in all your ways." Although Sarah loses her mother, the young woman discovers a renewed sense of hope and comes to understand the mysteriousness of God. As the inspirational film says, "Sometimes life takes things from us so that others will go in the right direction."